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Molecular evolution and targeted recombination of SARS-CoV-2 in South Koreaopen access

Authors
Demirev, Atanas V.Lee, KyuyoungBae, Joon-YongPark, HeedoPark, SejikKim, HyunbeenLee, JungminCho, JunhyungYang, Jeong-SunKim, Kyung-ChangLee, Joo-YeonKim, KisoonLemey, PhilippePark, Man-SeongKim, Jin Il
Issue Date
Sep-2023
Publisher
CELL PRESS
Citation
iScience, v.26, no.9
Indexed
SCIE
SCOPUS
Journal Title
iScience
Volume
26
Number
9
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/64228
DOI
10.1016/j.isci.2023.107689
ISSN
2589-0042
2589-0042
Abstract
SARS-CoV-2 variants have continuously emerged globally, including in South Korea. To characterize the molecular evolution of SARS-CoV-2 in South Korea, we performed phylogenetic and genomic recombination analyses using more than 12,000 complete genome sequences collected until October 2022. The variants in South Korea originated from globally identified variants of concern and harbored genetic cladecommon and clade-specific amino acid mutations mainly around the N-terminal domain (NTD) or receptor binding domain (RBD) in the spike protein. Several point mutation residues in key antigenic sites were under positive selection persistently with changing genetic clades of SARS-CoV-2. Furthermore, we detected 17 potential genomic recombinants and 76.4% (13/17) retained the mosaic NTD or RBD genome. Our results suggest that point mutations and genomic recombination in the spike contributed to the molecular evolution of SARS-CoV-2 in South Korea, which will form an integral part of global prevention and control measures against SARS-CoV-2.
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1. Basic Science > Department of Microbiology > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
4. Research institute > Institute for Viral Diseases > 1. Journal Articles

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