Complications of the Central Nervous System in Pediatric Patients With Common Cold Coronavirus Infection During 2014-2019open access
- Authors
- Park, Hwanhee; Kim, Kyung-Ran; Huh, Hee Jae; Yoon, Yoonsun; Park, Esther; Cho, Joongbum; Lee, Jiwon; Lee, Jeehun; Kim, Ji Hye; Kim, Yae-Jean
- Issue Date
- Nov-2023
- Publisher
- 대한의학회
- Keywords
- Common Cold Coronavirus; Central Nervous System Infection; Pediatrics; Immunocompromised
- Citation
- Journal of Korean Medical Science, v.38, no.46
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Korean Medical Science
- Volume
- 38
- Number
- 46
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65087
- DOI
- 10.3346/jkms.2023.38.e358
- ISSN
- 1011-8934
1598-6357
- Abstract
- Background: In pediatric patients, the common cold coronavirus (ccCoV) usually causes mild respiratory illness. There are reports of coronavirus causing central nervous system (CNS) infection in experimental animal models. Some immunocompromised patients have also been reported to have fatal CNS infections with ccCoV. The aim of this study was to investigate the clinical characteristics of CNS complications related to ccCoV infection.Methods: From January 2014 to December 2019, a retrospective analysis was performed of medical records from hospitalized patients under 19 years of age whose ccCoV was detected through polymerase chain reaction in respiratory specimens. The CNS complications were defined as clinically diagnosed seizure, meningitis, encephalopathy, and encephalitis.Results: A total of 436 samples from 420 patients were detected as ccCoV. Among the 420 patients, 269 patients were immunocompetent and 151 patients were immunocompromised. The most common type of ccCoV was OC43 (52% in immunocompetent, 37% in immunocompromised). CNS complications were observed in 9.4% (41/436). The most common type of CNS complication was the fever-provoked seizure under pre-existing neurologic disease (42% in immunocompetent and 60% in immunocompromised patients). Among patients with CNS complications, two immunocompetent patients required intensive care unit admission due to encephalitis. Three patients without underlying neurological disease started anti-seizure medications for the first time at this admission. There was no death related to ccCoV infection.Conclusion: ccCoV infection may cause severe clinical manifestations such as CNS complications or neurologic sequelae, even in previously healthy children.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 5. Others > ETC > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.