Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytesopen access
- Authors
- Jang, Hye-Yeon; Kim, Gi-Beum; Kim, Jeong-Mi; Kang, Sang Yull; Youn, Hyun-Jo; Park, Jinny; Ro, Su Yeon; Chung, Eun-Yong; Park, Kwang-Hyun; Kim, Jong-Suk
- Issue Date
- Dec-2023
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- fisetin; ultraviolet A; matrix metalloproteinase; NADPH oxidase; reactive oxygen stress
- Citation
- International Journal of Molecular Sciences, v.24, no.24
- Indexed
- SCIE
SCOPUS
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 24
- Number
- 24
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65106
- DOI
- 10.3390/ijms242417358
- ISSN
- 1661-6596
1422-0067
- Abstract
- Fisetin is a flavonoid found in plants and has been reported to be effective in various human diseases. However, the effective mechanisms of ultraviolet-A (UVA)-mediated skin damage are not yet clear. In this study, we investigated the protective mechanisms of fisetin regarding UVA-induced human dermal fibroblasts (HDFs) and human epidermal keratinocytes (HEKs) damages. Fisetin showed a cytoprotective effect against UVA irradiation and suppressed matrix metalloproteinases (MMPs), MMP-1, and MMP-3 expression. In addition, fisetin was rescued, which decreased mRNA levels of pro-inflammatory cytokines, reactive oxygen species production, and the downregulation of MAPK/AP-1 related protein and NADPH oxidase (NOX) mRNA levels. Furthermore, UVA-induced MMP-1 and MMP-3 were effectively inhibited by siRNAs to NOX 1 to 5 in HDFs and HEKs. These results indicate that fisetin suppresses UVA-induced damage through the NOX/ROS/MAPK pathway in HDFs and HEKs.
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