Increased Risk of Hip Fracture in Patients with Acromegaly: A Nationwide Cohort Study in Koreaopen access
- Authors
- Kim, Jiwon; Hong, Namki; Choi, Jimi; Moon, Ju Hyung; Kim, Eui Hyun; Lee, Eun Jig; Kim, Sin Gon; Ku, Cheol Ryong
- Issue Date
- Dec-2023
- Publisher
- 대한내분비학회
- Keywords
- Acromegaly; Hip fractures; Korea; Nationwide
- Citation
- Endocrinology and Metabolism, v.38, no.6, pp 690 - 700
- Pages
- 11
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Endocrinology and Metabolism
- Volume
- 38
- Number
- 6
- Start Page
- 690
- End Page
- 700
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65295
- DOI
- 10.3803/EnM.2023.1782
- ISSN
- 2093-596X
2093-5978
- Abstract
- Background: Acromegaly leads to various skeletal complications, and fragility fractures are emerging as a new concern in patients with acromegaly. Therefore, this study investigated the risk of fractures in Korean patients with acromegaly. Methods: We used the Korean nationwide claims database from 2009 to 2019. A total of 931 patients with acromegaly who had never used an osteoporosis drug before and were treated with surgery alone were selected as study participants, and a 1:29 ratio of 26,999 age- and sex-matched osteoporosis drug-naïve controls without acromegaly were randomly selected from the database. Results: The mean age was 46.2 years, and 50.0% were male. During a median follow-up of 54.1 months, there was no difference in the risks of all, vertebral, and non-vertebral fractures between the acromegaly and control groups. However, hip fracture risk was significantly higher (hazard ratio [HR], 2.73; 95% confidence interval [CI], 1.32 to 5.65), and non-hip and non-vertebral fractures risk was significantly lower (HR, 0.40; 95% CI, 0.17 to 0.98) in patients with acromegaly than in controls; these results remained robust even after adjustment for socioeconomic status and baseline comorbidities. Age, type 2 diabetes mellitus, cardio-cerebrovascular disease, fracture history, recent use of acid-suppressant medication, psychotropic medication, and opioids were risk factors for all fractures in patients with acromegaly (all P<0.05). Conclusion: Compared with controls, patients surgically treated for acromegaly had a higher risk of hip fractures. The risk factors for fracture in patients with acromegaly were consistent with widely accepted risk factors in the general population. © 2023 Korean Endocrine Society. All rights reserved.
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