Different risks of early-onset and late-onset Parkinson disease in individuals with mental illnessopen access
- Authors
- Yoon, Seo Yeon; Lee, Sang Chul; Suh, Jee Hyun; Yang, Seung Nam; Han, Kyungdo; Kim, Yong Wook
- Issue Date
- Jan-2024
- Publisher
- NATURE PORTFOLIO
- Citation
- npj Parkinson's disease, v.10, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- npj Parkinson's disease
- Volume
- 10
- Number
- 1
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65362
- DOI
- 10.1038/s41531-023-00621-x
- ISSN
- 2373-8057
- Abstract
- We aimed to investigate the association of various mental illnesses, including depression, bipolar disorder, schizophrenia, insomnia, and anxiety, with the risk of early-onset Parkinson's disease (EOPD) (age <50 years) and compare it with that of late-onset PD (LOPD) (age >= 50 years). This nationwide cohort study enrolled 9,920,522 people who underwent a national health screening examination in 2009, and followed up until 31 December 2018. There was a significantly increased risk of EOPD and LOPD in individuals with mental illness, and EOPD showed a stronger association than LOPD (EOPD, hazard ratio (HR) = 3.11, 95% CI: 2.61-3.72; LOPD, HR = 1.70, 95% CI: 1.66-1.74; p for interaction <0.0001). Our results suggest that people with mental illnesses aged < 50 years are at a higher risk of PD than those aged >= 50 years. Future studies are warranted to elucidate the pathomechanism of EOPD in relation to mental illness.
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