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Three-Year Cardiovascular Outcomes of Telmisartan in Patients With Hypertension: An Electronic Health Record-Based Cohort Study

Authors
Yum, YunjinKim, Ju HyeonJoo, Hyung JoonKim, Yong HyunKim, Eung Ju
Issue Date
Jan-2024
Publisher
Oxford University Press
Keywords
blood pressure; heart failure; hypertension; mortality; myocardial infarction; stroke; telmisartan
Citation
American Journal of Hypertension
Indexed
SCIE
SCOPUS
Journal Title
American Journal of Hypertension
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65516
DOI
10.1093/ajh/hpae012
ISSN
0895-7061
1941-7225
Abstract
BACKGROUND Telmisartan exhibits superior efficacy in controlling 24-h blood pressure (BP) compared with other angiotensin receptor blockers (ARBs). However, data on its cardiovascular effects in patients with hypertension are limited. This study aimed to evaluate the cardiovascular outcomes in patients taking telmisartan compared to those taking other ARBs.METHODS This multicenter retrospective study used data from the Korea University Medical Center database, built from electronic health records. A total of 19,247 patients taking two or more antihypertensive medications were identified. Patients prescribed telmisartan (telmisartan users) were compared with those prescribed an ARB other than telmisartan (other ARB users). The primary outcome was major adverse cardiac events (MACE), a composite of cardiovascular death, myocardial infarction, stroke, and hospitalizations due to heart failure. The adjusted outcomes were compared using 1:1 propensity score (PS) matching.RESULTS Overall, 3,437 (17.9%) patients were telmisartan users. These patients were more likely to be younger and male and less likely to have a history of chronic kidney disease, dialysis, or heart failure. In the PS-matched cohort, BP control was similar in both groups; however, telmisartan users exhibited significantly lower visit-to-visit BP variability. The adjusted 3-year MACE rate was similar between telmisartan users (4.6%) and other ARB users (4.7%, log-rank P = 0.75), with comparable safety profiles.CONCLUSIONS In real-world practice, telmisartan showed cardiovascular outcomes similar to those of other ARBs in patients with hypertension taking two or more antihypertensive drugs.
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Kim, Ju Hyeon
Anam Hospital (Department of Cardiology, Anam Hospital)
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