Clinicopathologic Characteristics of CD99-Positive Diffuse Large B-Cell Lymphoma
- Authors
- Lee, Sang Pyo; Park, Sanghui; Park, Jinny; Hong, Junshik; Ko, Young Hyeh
- Issue Date
- Mar-2011
- Publisher
- S. Karger AG
- Keywords
- Anaplastic carcinomas; CD99; Diffuse large B-cell carcinomas; Germinal center B cells; Lymphomas
- Citation
- Acta Haematologica, v.125, no.3, pp 167 - 174
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Acta Haematologica
- Volume
- 125
- Number
- 3
- Start Page
- 167
- End Page
- 174
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65722
- DOI
- 10.1159/000322551
- ISSN
- 0001-5792
1421-9662
- Abstract
- Background: CD99 immunoreactivity has been documented in a variety of tumors, including lymphoid malignancies such as anaplastic large-cell lymphomas. However, few studies have investigated the prognostic impact of CD99 in diffuse large B-cell lymphoma (DLBCL). Methods: Using conventional paraffin embedding, immunoperoxidase staining and tissue microarrays, we retrospectively investigated CD99 expression in 155 DLBCL patients. Results: Of the 155 DLBCL patients, 60 (38.7%) were positive for CD99. CD99 positivity was significantly associated with advanced stage (p < 0.01), higher risk group according to the International Prognostic Index risk score (p < 0.01) and non-germinal center B cell-like type (p = 0.01). The difference in progression-free survival (PFS) between CD99+ and CD99- groups was statistically significant (p = 0.04), even though the difference in overall survival was not (p = 0.74). Multivariate analysis demonstrated that CD99 expression was marginally correlated with PFS. Conclusion: To the best of our knowledge, this is the first report on the clinicopathologic characteristics of CD99+ DLBCL, particularly unique clinicopathologic features. Copyright (C) 2010 S. Karger AG, Basel
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