Risk of depression and anxiety in multiple sclerosis and neuromyelitis optica spectrum disorder: A nationwide cohort study in South Korea
- Authors
- Kwon, Soonwook; Han, Kyung-Do; Jung, Jin Hyung; Cho, Eun Bin; Chung, Yeon Hak; Park, Junhee; Choi, Hea Lim; Jeon, Hong Jin; Shin, Dong Wook; Min, Ju-Hong
- Issue Date
- Apr-2024
- Publisher
- SAGE Publications
- Keywords
- Depression; anxiety; multiple sclerosis; neuromyelitis optica spectrum disorder; risk
- Citation
- Multiple Sclerosis
- Indexed
- SCIE
SCOPUS
- Journal Title
- Multiple Sclerosis
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/66098
- DOI
- 10.1177/13524585241237093
- ISSN
- 1352-4585
1477-0970
- Abstract
- Background: We investigated the risks of depression/anxiety in patients with multiple sclerosis (pwMS) or patients with neuromyelitis optica spectrum disorder (pwNMOSD).Objectives: MS/NMOSD cohorts were collected from Korean National Health Insurance Service, using the International Classification of Diseases-10th and information on Rare Intractable Disease program. Patients who were younger than 20 years, had a previous depression/anxiety, or died in the index year were excluded.Methods: Hazard ratios (HRs) of depression/anxiety in pwMS and pwNMOSD from controls matched 1:5 for age, sex, hypertension, diabetes, and dyslipidemia were calculated using Cox regressions with a 1-year lag period and estimated over time.Results: During a mean follow-up of 4.1 years, adjusted hazard ratios (aHR) for depression were 3.25 (95% confidence interval (CI) = 2.59-4.07) in MS and 2.17 (1.70-2.76) in NMOSD, and aHRs for anxiety were 1.83 (1.49-2.23) in MS and 1.56 (1.26-1.91) in NMOSD. The risks of anxiety/depression did not differ between MS and NMOSD and were highest in the second year after diagnosis of MS/NMOSD. The relative risk of depression was higher in younger pwMS/pwNMOSD, and the relative risk of anxiety was higher in pwMS who was male, had low income, or lived in a non-urban area.Conclusion: The risk of depression and anxiety was increased in pwMS/pwNMOSD.
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