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Cited 72 time in webofscience Cited 62 time in scopus
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A nationwide seroepidemiology of hepatitis C virus infection in South Korea

Authors
Kim, Do YoungKim, In HeeJeong, Sook-HyangCho, Yong KyunLee, Joon HyoekJin, Young-JooLee, DonSuh, Dong JinHan, Kwang-HyubPark, Neung HwaKang, Ha YanJung, Young KulKim, Young SeokKim, Kyung-AhLee, Youn JaeLee, Byung SeokYim, Hyung JoonLee, Heon JuBaik, Soon KooTak, Won YoungLee, Sun JaeChung, Woo JinChoi, Sung-KyuCho, Eun-YoungHeo, JeongKim, Dong JoonSong, Byung-CheolKim, Man WooLee, JunChae, Hee BokChoi, Dae HeeChoi, Hwa YoungKi, Moran
Issue Date
Apr-2013
Publisher
WILEY
Keywords
hepatitis C virus; infection; Korea; prevalence
Citation
LIVER INTERNATIONAL, v.33, no.4, pp.586 - 594
Indexed
SCIE
SCOPUS
Journal Title
LIVER INTERNATIONAL
Volume
33
Number
4
Start Page
586
End Page
594
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10843
DOI
10.1111/liv.12108
ISSN
1478-3223
Abstract
Background & Aims The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey. Methods From January to December 2009, a total of 291314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed. Results Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78%. Anti-HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti-HCV positivity was observed, from 0.34% in those aged 2029years to 2.31% in those >70years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.532.07%), mid-level in Seoul and surrounding districts (0.500.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV () group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients. Conclusion The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.
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Jung, Young Kul
Ansan Hospital (Department of Gastroenterology and Hepatology, Ansan Hospital)
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