A nationwide seroepidemiology of hepatitis C virus infection in South Korea
- Kim, Do Young; Kim, In Hee; Jeong, Sook-Hyang; Cho, Yong Kyun; Lee, Joon Hyoek; Jin, Young-Joo; Lee, Don; Suh, Dong Jin; Han, Kwang-Hyub; Park, Neung Hwa; Kang, Ha Yan; Jung, Young Kul; Kim, Young Seok; Kim, Kyung-Ah; Lee, Youn Jae; Lee, Byung Seok; Yim, Hyung Joon; Lee, Heon Ju; Baik, Soon Koo; Tak, Won Young; Lee, Sun Jae; Chung, Woo Jin; Choi, Sung-Kyu; Cho, Eun-Young; Heo, Jeong; Kim, Dong Joon; Song, Byung-Cheol; Kim, Man Woo; Lee, Jun; Chae, Hee Bok; Choi, Dae Hee; Choi, Hwa Young; Ki, Moran
- Issue Date
- hepatitis C virus; infection; Korea; prevalence
- LIVER INTERNATIONAL, v.33, no.4, pp.586 - 594
- Journal Title
- LIVER INTERNATIONAL
- Start Page
- End Page
- Background & Aims The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey. Methods From January to December 2009, a total of 291314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed. Results Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78%. Anti-HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti-HCV positivity was observed, from 0.34% in those aged 2029years to 2.31% in those >70years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.532.07%), mid-level in Seoul and surrounding districts (0.500.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV () group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients. Conclusion The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.
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- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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