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Cited 2 time in webofscience Cited 2 time in scopus
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A Planned Prospective, Randomized, Placebo-Controlled Multicenter Trial Assessing the Effect of Helicobacter pylori Eradication on the Healing of Iatrogenic Ulcer after Endoscopic Resection of Gastric Neoplasmopen access

Authors
Kim, Sang GyunSong, Ho JuneChoi, Il JuCho, Joo YoungJung, Hwoon-YongKeum, BoraCheon, Jae HeeLee, Yong ChanKim, Jae GyuPark, Sue K.Park, Byung JooJung, Hyun Chae
Issue Date
Dec-2010
Publisher
EDITORIAL OFFICE GUT & LIVER
Keywords
Helicobacter pylori; Iatrogenic ulcer; Endoscopic resection; Eradication; Medical Research Collaboration Center
Citation
GUT AND LIVER, v.4, no.4, pp.514 - 517
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
GUT AND LIVER
Volume
4
Number
4
Start Page
514
End Page
517
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14292
DOI
10.5009/gnl.2010.4.4.514
ISSN
1976-2283
Abstract
Background/Aims: Helicobacter pylori eradication may facilitate the healing of iatrogenic ulcer after endoscopic resection of gastric neoplasm. This study involved designing a randomized, double-blinded, placebo-controlled, multicenter trial, performed by the Korean College of Helicobacter and Upper Gastrointestinal Research and the Medical Research Collaboration Center, Seoul National University Hospital. Methods: We intend to enroll up to 232 patients H.-pylori-positive patients who have gastric adenoma or early gastric cancer after endoscopic resection. The enrolled patients are being randomly allocated to the H.-pylori-eradication-plus-proton-pump-inhibitor group or the placebo-plus-proton-pump-inhibitor group based on their histology results and the size of the resected specimen. After random allocation, the iatrogenic ulcer size and stage are evaluated at 4- and 8-week follow-ups (with a window of 7 days). The primary end point is the healing rate of the ulcer by stage, and the secondary end point is the rate of ulcer size reduction, relief rate from ulcer-related symptoms, and adverse-event rates. Results: More than 90% of the target subjects have already been enrolled into the study and are receiving ongoing periodic monitoring by the Medical Research Collaboration Center. Conclusions: Completion of the study should reveal whether H. pylori eradication can facilitate the healing of ulcer after endoscopic resection in Korea. (Gut Liver 2010;4:514-517)
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Keum, Bora
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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