Relationship between the serum CA-125 level and bone mineral density in healthy pre- and post-menopausal women
- Authors
- Ahn, Ki Hoon; Park, Hyun Tae; Kim, Tak; Hur, Jun Young; Kim, Young Tae; Lee, Kyu Wan; Kim, Sun Haeng
- Issue Date
- Aug-2010
- Publisher
- WILEY
- Keywords
- bone mineral density; carbohydrate antigen-125; pre- and post-menopausal women
- Citation
- AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, v.50, no.4, pp 371 - 377
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
- Volume
- 50
- Number
- 4
- Start Page
- 371
- End Page
- 377
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14664
- DOI
- 10.1111/j.1479-828X.2010.01183.x
- ISSN
- 0004-8666
1479-828X
- Abstract
- Background: Osteoporosis and tumour-associated antigen (TAA) levels are associated with inflammatory processes, but little remains known about TAA levels and bone mineral density (BMD). Aims: We determined whether or not high-normal TAA levels are associated with a lower BMD in healthy women. Methods: A total of 3769 healthy women were enrolled from the health screening programme over 5 years. Each participant had undergone a basic health examination. Serum carbohydrate antigen (CA)-125, CA-19-9, carcinoembryonic antigen (CEA) and alpha-fetoprotein levels were evaluated as tumour markers. The correlations between serum TAA levels and BMD were analysed. Results: Carbohydrate antigen 125 and CEA levels were positively associated with a higher BMD in the pre-menopause. In the post-menopause, the CA-125 level was positively associated with BMD. In the pre-menopause, CA-125 (r = 0.102; P < 0.001) and CEA levels (r = 0.134; P < 0.001) had a significant correlation with BMD. In the post-menopause, CA-125 was negatively associated with alkaline phosphatase (r = -0.298; P < 0.001). Conclusions: There was a significant positive association between CA-125 and BMD in healthy women. Additional basic and clinical studies on the relationship between CA-125 and bone are needed.
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- Appears in
Collections - 2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
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