Usefulness of Non-invasive Markers for Predicting Significant Fibrosis in Patients with Chronic Liver Disease
- Authors
- Lee, Han Hyo; Seo, Yeon Seok; Um, Soon Ho; Won, Nam Hee; Yoo, Hanna; Jung, Eun Suk; Kwon, Yong Dae; Park, Sanghoon; Keum, Bora; Kim, Yong Sik; Yim, Hyung Joon; Jeen, Yoon Tae; Chun, Hoon Jai; Kim, Chang Duck; Ryu, Ho Sang
- Issue Date
- Jan-2010
- Publisher
- 대한의학회
- Keywords
- Liver Cirrhosis; Biological Markers; Chronic Liver Disease
- Citation
- Journal of Korean Medical Science, v.25, no.1, pp 67 - 74
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
KCI
- Journal Title
- Journal of Korean Medical Science
- Volume
- 25
- Number
- 1
- Start Page
- 67
- End Page
- 74
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15241
- DOI
- 10.3346/jkms.2010.25.1.67
- ISSN
- 1011-8934
1598-6357
- Abstract
- The purpose of this prospective study was to verify and compare the strengths of various blood markers and fibrosis models in predicting significant liver fibrosis. One hundred fifty-eight patients with chronic liver disease who underwent liver biopsy were enrolled. The mean age was 41 yr and male patients accounted for 70.2%. The common causes of liver disease were hepatitis B (67.7%) and C (16.5%) and fatty liver (9.5%). Stages of liver fibrosis (F0-4) were assessed according to the Batts and Ludwig scoring system. Significant fibrosis was defined as >= F2. Sixteen blood markers were measured along with liver biopsy, and estimates of hepatic fibrosis were calculated using various predictive models. Predictive accuracy was evaluated with a receiver-operating characteristics (ROC) curve. Liver biopsy revealed significant fibrosis in 106 cases (67.1%). On multivariate analysis, alpha 2-macroglobulin, hyaluronic acid, and haptoglobin were found to be independently related to significant hepatic fibrosis. A new predictive model was constructed based on these variables, and its area under the ROC curve was 0.91 (95% confidence interval, 0.85-0.96). In conclusion, alpha 2-macroglobulin, hyaluronic acid, and haptoglobin levels are independent predictors for significant hepatic fibrosis in chronic liver disease.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 1. Basic Science > Department of Pathology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15241)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.