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Cited 8 time in webofscience Cited 9 time in scopus
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Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism

Authors
Cho, Chul-HyunKang, Seung-GulChoi, Jung-EunPark, Young-MinLee, Heon-JeongKim, Leen
Issue Date
Sep-2009
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Keywords
Restless legs syndrome; Antipsychotic; Schizophrenia; Tyrosine hydroxylase; Polymorphism
Citation
PSYCHIATRY INVESTIGATION, v.6, no.3, pp.211 - 215
Indexed
SCIE
SCOPUS
KCI
OTHER
Journal Title
PSYCHIATRY INVESTIGATION
Volume
6
Number
3
Start Page
211
End Page
215
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15798
DOI
10.4306/pi.2009.6.3.211
ISSN
1738-3684
Abstract
Objective Restless legs syndrome (RLS) has been reported to be more prevalent in schizophrenic patients who take, antipsychotics. The cause of RLS is unknown but associated with dopaminergic deficiency. Tyrosine hydroxylase (TH) is the enzyme responsible for catalyzing the conversion of tyrosine to DOPA. The purpose of this study is to determine whether the TH gene Val81Met polymorphism is associated with antipsychotic-induced RLS. Methods One hundred ninety Korean schizophrenic patients were evaluated by the diagnostic criteria of the International RLS Study Group (IRLSSG). The genotyping was performed by PCR-based methods. Results Of the hundred ninety schizophrenic patients, 44 (23.2%) were found to have RLS. Although there were no significant associations between TH genotypes or allele frequencies and RLS, when separate analyses were performed by sex (male or female), we significant differences in the frequencies of the genotype (chi(2)=6.15, p=0.046) and (chi(2)=4.67, p=0.031) of the TH gene Val81 polymorphism between those with and without RLS in the female the patients. Conclusion These findings suggest that the TH gene Val81Met SNP might be associated with antipsychotic-induced RLS in female schizophrenic patients.
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Lee, Heon Jeong
Anam Hospital (Department of Psychiatry, Anam Hospital)
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