Significance of anti-HCV signal-to-cutoff ratio in predicting hepatitis C viremia
- Authors
- Seo Y.S.; Jung E.S.; Kim J.H.; Jung Y.K.; Kim J.H.; An H.; Yim H.J.; Yeon J.E.; Byun K.S.; Kim C.D.; Ryu H.S.; Um S.H.
- Issue Date
- 2009
- Keywords
- Antibody titer; Enzyme immunoassay; Hepatitis C virus; Viremia
- Citation
- Korean Journal of Internal Medicine, v.24, no.4, pp 302 - 308
- Pages
- 7
- Indexed
- SCOPUS
KCI
- Journal Title
- Korean Journal of Internal Medicine
- Volume
- 24
- Number
- 4
- Start Page
- 302
- End Page
- 308
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16523
- DOI
- 10.3904/kjim.2009.24.4.302
- ISSN
- 1226-3303
2005-6648
- Abstract
- Background/Aims: Hepatitis C virus (HCV) RNA testing can be performed using qualitative or quantitative assays, and it is still unclear which is more useful as a primary test in patients positive for anti-HCV. The present study evaluated the usefulness of anti-HCV signal-to-cutoff ratio (S/CO ratio) for predicting HCV RNA results. Methods: Patients on whom a qualitative HCV RNA test was performed due to a positive anti-HCV enzyme immunoassay were enrolled. Patients were divided into viremia and no-viremia groups according to HCV RNA results. Receiver-operating characteristic (ROC) curve analysis was performed to evaluate the diagnostic accuracy of anti-HCV S/CO for a diagnosis of viremia. Results: In total, 487 patients were enrolled. HCV RNA was positive in 301 subjects (61.8%). Age, serum ALT level, and anti-HCV S/CO ratio were significantly different between the viremia and no-viremia groups. By ROC curve analysis, anti-HCV S/CO ratio (area, 0.989; 95% confidence interval, 0.981 to 0.998) accurately predicted the presence of viremia, with a cutoff value of 10.9 (sensitivity, 94.4%; specificity, 97.3%). Conclusions: Anti-HCV S/CO ratio was found to be highly accurate at predicting HCV viremia. The anti-HCV S/CO ratio can be used to determine whether a quantitative or qualitative HCV RNA test should be used to confirm HCV viremia in patients with a positive anti-HCV by the following criteria: if the anti-HCV S/CO ratio is <10.9, a qualitative HCV RNA test can be used, and if the anti-HCV S/CO ratio is ≥10.9 a quantitative HCV RNA test can be performed.
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- Appears in
Collections - 1. Basic Science > Department of Biostatistics > 1. Journal Articles
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
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