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Cited 5 time in webofscience Cited 5 time in scopus
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Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

Authors
Seo, Yeon SeokKim, Ji HoonYeon, Jong EunPark, Jong-JaeKim, Jae SeonByun, Kwan SooBak, Young-TaeLee, Chang Hong
Issue Date
Aug-2007
Publisher
Baishideng Publishing Group
Keywords
Chronic hepatitis B; Lamivudine; Adefovir; Treatment efficacy
Citation
World Journal of Gastroenterology, v.13, no.30, pp 4072 - 4079
Pages
8
Indexed
SCOPUS
Journal Title
World Journal of Gastroenterology
Volume
13
Number
30
Start Page
4072
End Page
4079
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17795
DOI
10.3748/wjg.v13.i30.4072
ISSN
1007-9327
2219-2840
Abstract
AIM: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-naïve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV. METHODS: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay), and HBV DNA response (either HBV DNA level ≤ 105 copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level). RESULTS: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026). The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV. CONCLUSION: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naïve patients during the early course of treatment.
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Park, Jong Jae
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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