Reduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats
- Authors
- Sung, Su Ah; Jo, Sang Kyung; Cho, Won Yong; Won, Nam Hee; Kim, Hyoung Kyu
- Issue Date
- 2007
- Publisher
- KARGER
- Keywords
- liposome-encapsulated clodronate; macrophages; unilateral ureteral obstruction; renal fibrosis
- Citation
- NEPHRON EXPERIMENTAL NEPHROLOGY, v.105, no.1, pp E1 - E9
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEPHRON EXPERIMENTAL NEPHROLOGY
- Volume
- 105
- Number
- 1
- Start Page
- E1
- End Page
- E9
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18432
- DOI
- 10.1159/000096859
- ISSN
- 1660-2129
- Abstract
- Background/Aim: Macrophages have been thought to play a role in renal tubulointerstitial fibrosis; recent reports have demonstrated an antifibrotic effect of macrophages in late-stage renal fibrosis. Liposome-encapsulated clodronate (LC) produces a selective and systemic depletion of phagocytic macrophages in vivo. To study the role of initial infiltrating macrophages in renal fibrosis, we compared the effects of pretreatment with LC and a liposome vehicle for control of the severity of renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Methods: One day after a single intravenous injection of LC or liposome vehicle, the rats underwent UUO. Following 1, 5, and 14 days, the kidneys were examined to evaluate macrophage infiltration and renal fibrosis. Results: LC depleted macrophages systemically and reduced renal fibrosis associated with UUO; this beneficial effect was accompanied by a decrease of transforming growth factor beta mRNA expression. The osteopontinex-pression was also reduced by pretreatment with LC. Conclusion: Initial interstitial infiltration of macrophages contributes to tubulointerstitial fibrosis in UUO. Copyright (c) 2007 S. Karger AG, Basel.
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- Appears in
Collections - 1. Basic Science > Department of Pathology > 1. Journal Articles
- 2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
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