Weight gain associated with the alpha(2a)-adrenergic receptor-1291 C/G polymorphism and olanzapine treatment
- Authors
- Park, Young-Min; Chung, Young-Cho; Lee, Seung-Hwan; Lee, Kaug-Joon; Kim, Hyun; Byun, Young-Chan; Lim, Se-Won; Paik, Jong-Woo; Lee, Heon-Jeong
- Issue Date
- 5-Jun-2006
- Publisher
- WILEY
- Keywords
- olanzapine; weight gain; alpha(2a)-adrenergic receptor; polymorphisms; schizophrenia
- Citation
- AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, v.141B, no.4, pp 394 - 397
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
- Volume
- 141B
- Number
- 4
- Start Page
- 394
- End Page
- 397
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18777
- DOI
- 10.1002/ajmg.b.30311
- ISSN
- 1552-4841
1552-485X
- Abstract
- Weight gain can be an adverse effect of antipsychotics and is an important factor for long-term health and treatment compliance. Many reports have shown that the alpha(2)-adrenergic receptor may be related to eating behaviors or lipolytic activities, both associated with body weight change. We hypothesized that there might be a relationship between the (alpha 2a)-adrenergic receptor -1291 C/G polymorphism. and olanzapine-induced weight gain. A group of 62 Korean schizophrenic patients participated in a study; weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the -1291 C/G polymorphism was performed on all participants. Body weight changes from baseline to endpoint were significantly associated with genotypes (P = 0.028). The frequency of the G allele was significantly higher in subjects who had severe weight gain (defined as a more than 10% weight gain from baseline) compared to subjects who did not have extreme weight gain (less than 10% weight gain from baseline) (X-2 = 6.120, P = 0.013; OR = 2.58, 95% CI = 1.21-5.51). Therefore, the findings from this study support a relationship between the -1291 C/ G polymorphism of the alpha(2a)-adrenergic receptor and weight gain in Korean schizophrenic patients receiving olanzapine treatment. (c) 2006 Wiley-Liss, Inc.
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- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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