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Comparison of the effectiveness of quadruple salvage regimen for Helicobacter pylori infection according to the duration of treatment

Authors
Choung R.S.Lee S.W.Jung S.W.Han W.S.Kim M.J.Jeen Y.T.Park J.J.Lee H.S.Chun H.J.Um S.H.Choi J.H.Kim C.D.Ryu H.S.Hyun J.H.
Issue Date
Feb-2006
Keywords
Helicobacter pylori; Second-line quadruple therapy; Duration of treatment
Citation
The Korean journal of gastroenterology, v.47, no.2, pp.131 - 135
Indexed
SCOPUS
KCI
Journal Title
The Korean journal of gastroenterology
Volume
47
Number
2
Start Page
131
End Page
135
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19255
ISSN
1598-9992
Abstract
BACKGROUND/AIMS: At present, triple therapy schemes are recommended by national and international consensus conferences for the treatment of Helicobacter pylori (H. pylori) infection. However, even with the most effective current treatment regimens, about 10-20% of patients fail to eradicate H. pylori, necessitating alternative strategy to eradicate H. pylori in primary treatment failure. Therefore, we performed this study to evaluate the efficacy of quadruple therapy and to compare 1 and 2-week quadruple regimen as a second-line therapy. METHODS: The hospital records of 155 patients who failed to the standard triple therapy (proton pump inhibitor, amoxicillin, clarithromycin) were reviewed retrospectively, and divided the 1 or 2 weeks OBMT regimen (omeprazole 20 mg bid, bismuth salt 120 mg qid, metronidazole 500 mg tid, tetracycline 500 mg qid). Presence of H. pylori infection and side-effects of the treatment regimen were assessed 4 weeks after the cessation of treatment. RESULTS: One hundred and eight male and 47 female (mean age, 52.2+/-15.4) patients were enrolled. The overall eradication rate of H. pylori with quadruple therapy was 83.9% and the eradication rate was similar between 1 and 2 weeks of OBMT regimen (76.8% in OBMT 1 week, 87.9% in OBMT 2 weeks, respectively p=0.110). CONCLUSIONS: Quadruple therapy is an effective salvage regimen for H. pylori eradication after the failure of standard triple therapy. One week quadruple therapy is not significantly different from 2-weeks regimen as the second-line option for H. pylori eradication.
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Jeen, Yoon Tae
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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