Association between the catechol O-methyltransferase Val108/158Met polymorphism and alexithymia
- Authors
- Ham, BJ; Lee, MS; Lee, YM; Kim, MK; Choi, MJ; Oh, KS; Jung, HY; Lyoo, IK; Choi, IG
- Issue Date
- 2005
- Publisher
- KARGER
- Keywords
- alexithymia; catechol O-methyltransferase; 5-HTTLPR polymorphism
- Citation
- NEUROPSYCHOBIOLOGY, v.52, no.3, pp 151 - 154
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROPSYCHOBIOLOGY
- Volume
- 52
- Number
- 3
- Start Page
- 151
- End Page
- 154
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20173
- DOI
- 10.1159/000087846
- ISSN
- 0302-282X
1423-0224
- Abstract
- It has been suggested that the characteristics of alexithymia result from deficits in frontal lobe functioning, and the prefrontal cortex is particularly dependent on the catechol O-methyltransferase (COMT) pathway. We investigated the relationship between COMT Val108/158Met, serotonin transporter coding sequence (5-HT transporter gene-linked polymorphic region; 5-HTTLPR) polymorphisms, and alexithymia. The study sample comprised 109 students at the Korea University. All participants were tested using the 20-item Toronto Alexithymia Scale (TAS-20). They were genotyped for COMT Val108/158Met and 5-HTTLPR polymorphisms. Genotyping was analyzed using polymerase chain reaction. Subjects with Val/Val genotype had significantly higher TAS-20 scores than those with Met/Met or Met/Val genotypes. However, there was no significant relationship between the 5-HTTLPR genotype and TAS-20 scores. This indicates a possible association between the COMT Val108/158Met gene polymorphism and alexithymia. Copyright (C) 2005 S. Karger AG, Basel.
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Collections - 1. Basic Science > Department of Biochemistry and Molecular Biology > 1. Journal Articles
- 1. Basic Science > Department of Medical Education > 1. Journal Articles
- 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
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