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α-fetoprotein impairs APC function and induces their apoptosis

Authors
Um S.H.Mulhall C.Alisa A.Ives A.R.Karani J.Williams R.Bertoletti A.Behboudi S.
Issue Date
Aug-2004
Publisher
American Association of Immunologists
Citation
Journal of Immunology, v.173, no.3, pp.1772 - 1778
Indexed
SCOPUS
Journal Title
Journal of Immunology
Volume
173
Number
3
Start Page
1772
End Page
1778
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20882
DOI
10.4049/jimmunol.173.3.1772
ISSN
0022-1767
Abstract
α-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of dendritic cells (DCs). This was demonstrated by the down-regulation of CD40 and CD86 molecnles and the impairment of allostimulatory function. Also, AFP was found to induce significant apoptosis of DCs, and AFP-treated DCs produced low levels of IL-12 and TNF-α, a cytokine pattern that could hamper an efficient antitumor immune response. Ex vivo, APCs of patients with HCC and high levels of AFP produced lower levels of TNF-α than that of healthy individuals. In conclusion, these results illustrate that AFP induces dysfunction and apoptosis of APCs, thereby offering a mechanism by which HCC escapes immunological control.
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