Complex-oligosaccharide composed of galacto-oligosaccharide and lactulose ameliorates loperamide-induced constipation in rats
- Authors
- Kwon, Jung Il; Park, Yooheon; Noh, Dong Ouk; Suh, Hyung Joo; Han, Sung Hee
- Issue Date
- Jun-2018
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- GOS; Lactulose; Oligosaccharides; Constipation; Short-chain fatty acids; Crypt cell
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.27, no.3, pp 781 - 788
- Pages
- 8
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 27
- Number
- 3
- Start Page
- 781
- End Page
- 788
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3496
- DOI
- 10.1007/s10068-017-0300-2
- ISSN
- 1226-7708
2092-6456
- Abstract
- The purpose of this study was to compare the beneficial effects of galactooligosaccharide (GOS), lactulose, and a complex-oligosaccharide composed with GOS and lactulose (Com-oligo) on loperamide-induced constipation in SD rats. Rats were randomly divided into the following eight groups: the normal group (Nor); constipation control group (Con); and 6 constipation groups fed low and high doses of GOS, lactulose (Lac), and Com-oligo, respectively. Com-oligo increased intestinal transit ratio and relieved constipation in loperamide-treated rats. The group receiving a high dose of Com-oligo favorably regulated gastrointestinal functions such as pellet number, weight, moisture content, short chain fatty acid, intestinal transit ratio, and bifidobacterium number in constipated rats. In addition, Com-oligo restored peristalsis of the small intestine, morphology of colon, and increased interstitial cells of Cajal area. Thus, providing Com-oligo as an oligosaccharide ingredient in nutritional formulas could benefit the health of the gastrointestinal tract.
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Collections - 4. Research institute > Institute of Human Behavior and Genetics > 1. Journal Articles
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