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Impact of Young Age at Diagnosis on Survival in Patients with Surgically Treated Renal Cell Carcinoma: A Multicenter Studyopen access

Authors
Kang, Ho WonSeo, Sung PilKim, Won TaeYun, Seok JoongLee, Sang-CheolKim, Wun-JaeHwang, Eu ChangKang, Seok HoHong, Sung-HooChung, JinsooKwon, Tae GyunKim, Hyeon HoeKwak, CheolByun, Seok-SooKim, Yong-June
Issue Date
Dec-2016
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Renal Cell Carcinoma; Nephrectomy; Age; Recurrence; Survival
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.31, no.12, pp 1976 - 1982
Pages
7
Indexed
SCI
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
31
Number
12
Start Page
1976
End Page
1982
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/5806
DOI
10.3346/jkms.2016.31.12.1976
ISSN
1011-8934
1598-6357
Abstract
The prognostic significance of age in renal cell carcinoma (RCC) is a subject of debate. The aim of the present multi-institutional study was to evaluate the impact of age on clinicopathological features and survival in a large cohort of patients with RCC. A total of 5,178 patients who underwent surgery for RCC at eight institutions in Korea between 1999 and 2011 were categorized into three groups according to age at diagnosis as follows: young age (< 40 years, n= 541), middle-age (>= 40 and < 60 years, n= 2,551), and old age (>= 60 years, n= 2,096) groups. Clinicopathological variables and survival rates were compared between the three groups. Young patients had lower stage tumors with a low Fuhrman grade, a lower rate of lymphovascular invasion than patients in the other age groups. Regarding histologic type, the young age group had a lower percentage of clear cell histology and a greater incidence of Xp11.2 translocation RCC. Kaplan-Meier estimates showed that cancer-specific survival was significantly better in the young age group than in the other groups (log rank test, P = 0.008). However, age at diagnosis was not an independent predictor of survival in multivariate analysis. In conclusion, young age at diagnosis was associated with favorable pathologic features, although it was not an independent prognostic factor for survival in patients with surgically-treated RCC. Age itself should not be regarded as a crucial determinant for the treatment of RCC.
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