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Cited 45 time in webofscience Cited 50 time in scopus
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BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation

Authors
Kim, Bo RamOh, Sang CheulLee, Dae-HeeKim, Jung LimLee, Suk YoungKang, Myoung HeeLee, Sun IlKang, SangheeJoung, Sung YupMin, Byung Wook
Issue Date
Dec-2015
Publisher
SAGE PUBLICATIONS LTD
Keywords
Colon cancer; Bone morphogenetic proteins; Cancer stem cells; Epithelial-mesenchymal transition; Signal transducer and activator of transcription 3
Citation
TUMOR BIOLOGY, v.36, no.12, pp.9475 - 9486
Indexed
SCIE
SCOPUS
Journal Title
TUMOR BIOLOGY
Volume
36
Number
12
Start Page
9475
End Page
9486
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/7255
DOI
10.1007/s13277-015-3681-y
ISSN
1010-4283
Abstract
Bone morphogenetic proteins (BMPs) have been involved in metastatic progression and tumorigenesis of many cancer types. However, it remains unclear how BMP-2 contributes to the initiation and development of these cancers. Here, we investigated the role of BMP-2 in colon cancer stem cell (CSC) development from colon cancer cells. We also determined the effects of BMP-2 on CSC development and epithelial-mesenchymal transition (EMT) in human colon cancer cell lines HCT-116 and SW620. We found that BMP-2 enhanced sphere formation of colon cancer cells without serum. Also, BMP-2-induced spheres displayed up-regulation of stemness markers (CD133+ and EpCAM+) and increased drug resistance, hallmarks of CSCs. Importantly, expression of EMT activators p-Smad1/5 and Snail and N-cadherin was increased in the spheres' cells, indicating that BMP-2 signaling might result in CSC self-renewal and EMT. Furthermore, siRNA-mediated knockdown of signal transducer and activator of transcription 3 (STAT3) in HCT-116 cells reversed BMP-2-induced EMT and stem cell formation. Taken together, our results suggest that the BMP-2 induced STAT3-mediated induction of colon cancer cell metastasis requires an EMT and/or changes in CSC markers.
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2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
4. Research institute > Institute of Convergence New Drug Development > 1. Journal Articles

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Lee, Sun Il
Guro Hospital (Department of Colon and Rectal Surgery, Guro Hospital)
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