The prevalence rate of tuberculin skin test positive by contacts group to predict the development of active tuberculosis after school outbreaks
- Authors
- Kim H.J.; Chun B.C.; Kwon A.M.; Lee G.-H.; Ryu S.; Oh S.Y.; Lee J.B.; Yoo S.H.; Kim E.S.; Kim J.H.; Shin C.; Lee S.H.
- Issue Date
- 2015
- Publisher
- Korean National Tuberculosis Association
- Keywords
- Adolescent; Disease outbreaks; Latent tuberculosis; Tuberculin test; Tuberculosis
- Citation
- Tuberculosis and Respiratory Diseases, v.78, no.4, pp 349 - 355
- Pages
- 7
- Indexed
- SCOPUS
KCI
- Journal Title
- Tuberculosis and Respiratory Diseases
- Volume
- 78
- Number
- 4
- Start Page
- 349
- End Page
- 355
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/8424
- DOI
- 10.4046/trd.2015.78.4.349
- ISSN
- 1738-3536
2005-6184
- Abstract
- Background: The tuberculin skin test (TST) is the standard tool to diagnose latent tuberculosis infection (LTBI) in mass screening. The aim of this study is to find an optimal cut-off point of the TST+ rate within tuberculosis (TB) contacts to predict the active TB development among adolescents in school TB outbreaks. Methods: The Korean National Health Insurance Review and Assessment database was used to identify active TB development in relation to the initial TST (cut-off, 10 mm). The 7,475 contacts in 89 schools were divided into two groups: Incident TB group (43 schools) and no incident TB group (46 schools). LTBI treatment was initiated in 607 of the 1,761 TST+ contacts. The association with active TB progression was examined at different cut-off points of the TST+ rate. Results: The mean duration of follow-up was 3.9±0.9 years. Thirty-three contacts developed active TB during the 4,504 person-years among the TST+ contacts without LTBI treatment (n=1,154). The average TST+ rate for the incident TB group (n=43) and no incident TB group (n=46) were 31.0% and 15.5%, respectively. The TST+ rate per group was related with TB progression (odds ratio [OR], 1.025; 95% confidence interval [CI], 1.001-1.050; p=0.037). Based on the TST+ rate per group, active TB was best predicted at TST+ ≥ 16% (OR, 3.11; 95% CI, 1.29-7.51; area under curve, 0.64). Conclusion: Sixteen percent of the TST+ rate per group within the same grade students can be suggested as an optimal cut-off to predict active TB development in middle and high schools TB outbreaks. Copyright © 2015 The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.
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- Appears in
Collections - 2. Clinical Science > Department of Pulmonary, Allergy, and Critical Care Medicine > 1. Journal Articles
- 1. Basic Science > Department of Preventive Medicine > 1. Journal Articles
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