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Preclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model

Authors
Choi, Jung-WooLee, JoonbumLee, YuseonSeo, Ji-HunHong, Kwang Dae
Issue Date
Apr-2022
Publisher
Royal Society of Chemistry
Citation
Journal of Materials Chemistry B, v.10, no.14, pp.2708 - 2718
Indexed
SCIE
SCOPUS
Journal Title
Journal of Materials Chemistry B
Volume
10
Number
14
Start Page
2708
End Page
2718
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55337
DOI
10.1039/d1tb02341a
ISSN
2050-750X
Abstract
Fecal incontinence is a disabling condition in which the passage of fecal material cannot be controlled. Although the condition is not life-threatening, it can seriously reduce the quality of life of a patient by isolating them from others. Though various surgical treatments are available for moderate to severe symptoms, a bulking agent is a minimally invasive technique that has attracted attention because of its safety and simple treatment process. However, the biocompatibility of bulking agent materials remains a central issue, with their durability questioned because immune responses and/or the circulatory system may remove the bulking agent in vivo. This study investigated a bulking agent composed of polydimethylsiloxane and hyaluronic acid as a microfiller and carrier gel, respectively. To improve the injectability of the bulking agent, the filler size was tuned using a suspension-based fabrication technique. To evade immune responses, the filler surface was treated with a zwitterionic polymer that simultaneously functionalized and stabilized the material interfaces. The resulting bulking agent exhibited good injectability and biocompatibility in vitro, with 58% lower protein adsorption and no cytotoxicity, leading to an improved bulking effect in a preclinical rat model compared with a bulking agent without surface treatment. These results illustrate the promising potential of bulking agents as a therapy for fecal incontinence with reduced foreign body reactions and long-lasting efficacy.
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2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
2. Clinical Science > Department of Pathology > 1. Journal Articles

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Choi, Jung Woo
Ansan Hospital (Department of Pathology, Ansan Hospital)
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