Preclinical testing of an anal bulking agent coated with a zwitterionic polymer in a fecal incontinence rat model
- Authors
- Choi, Jung-Woo; Lee, Joonbum; Lee, Yuseon; Seo, Ji-Hun; Hong, Kwang Dae
- Issue Date
- Apr-2022
- Publisher
- Royal Society of Chemistry
- Citation
- Journal of Materials Chemistry B, v.10, no.14, pp 2708 - 2718
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Materials Chemistry B
- Volume
- 10
- Number
- 14
- Start Page
- 2708
- End Page
- 2718
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/55337
- DOI
- 10.1039/d1tb02341a
- ISSN
- 2050-750X
2050-7518
- Abstract
- Fecal incontinence is a disabling condition in which the passage of fecal material cannot be controlled. Although the condition is not life-threatening, it can seriously reduce the quality of life of a patient by isolating them from others. Though various surgical treatments are available for moderate to severe symptoms, a bulking agent is a minimally invasive technique that has attracted attention because of its safety and simple treatment process. However, the biocompatibility of bulking agent materials remains a central issue, with their durability questioned because immune responses and/or the circulatory system may remove the bulking agent in vivo. This study investigated a bulking agent composed of polydimethylsiloxane and hyaluronic acid as a microfiller and carrier gel, respectively. To improve the injectability of the bulking agent, the filler size was tuned using a suspension-based fabrication technique. To evade immune responses, the filler surface was treated with a zwitterionic polymer that simultaneously functionalized and stabilized the material interfaces. The resulting bulking agent exhibited good injectability and biocompatibility in vitro, with 58% lower protein adsorption and no cytotoxicity, leading to an improved bulking effect in a preclinical rat model compared with a bulking agent without surface treatment. These results illustrate the promising potential of bulking agents as a therapy for fecal incontinence with reduced foreign body reactions and long-lasting efficacy.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Colon and Rectal Surgery > 1. Journal Articles
- 2. Clinical Science > Department of Pathology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.