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Altered TIMP-3 Levels in the Cerebrospinal Fluid and Plasma of Patients with Alzheimer's Diseaseopen access

Authors
Park, Jung HyunCho, Sun-JungJo, ChulmanPark, Moon HoHan, ChangsuKim, Eun-JooHuh, Gi YeongKoh, Young Ho
Issue Date
May-2022
Publisher
MDPI AG
Keywords
TIMP-3; CSF; Plasma; Alzheimer' s disease
Citation
Journal of Personalized Medicine, v.12, no.5
Indexed
SCIE
SCOPUS
Journal Title
Journal of Personalized Medicine
Volume
12
Number
5
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61047
DOI
10.3390/jpm12050827
Abstract
Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment and is suggested to play an indirect role in regulating A beta production and the pathophysiology of A beta deposition in brains. However, studies on the amount of TIMP-3 in bodily fluids of Alzheimer's disease (AD) patients have not been conducted. Here, we investigated the relationship between fluid TIMP-3 levels and AD pathology. We first showed that the fluid levels of TIMP-3 were lower in AD dementia patients compared with in non-AD patients. ELISA results revealed that plasma levels of TIMP-3 in 65 patients with AD were significantly lower than those in 115 healthy control subjects and 71 mild cognitive impairment (MCI) subjects. Furthermore, we found that cerebrospinal fluid (CSF) level of TIMP-3 was decreased in AD compared with that in healthy control. These data suggest that fluid TIMP-3 levels negatively correlated with progress of cognitive decline. Collectively, our study suggests that alterations of fluid TIMP-3 levels might be associated with AD pathology.
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2. Clinical Science > Department of Psychiatry > 1. Journal Articles
2. Clinical Science > Department of Neurology > 1. Journal Articles

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Park, Moon Ho
Ansan Hospital (Department of Neurology, Ansan Hospital)
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