Altered TIMP-3 Levels in the Cerebrospinal Fluid and Plasma of Patients with Alzheimer's Diseaseopen access
- Authors
- Park, Jung Hyun; Cho, Sun-Jung; Jo, Chulman; Park, Moon Ho; Han, Changsu; Kim, Eun-Joo; Huh, Gi Yeong; Koh, Young Ho
- Issue Date
- May-2022
- Publisher
- MDPI AG
- Keywords
- TIMP-3; CSF; Plasma; Alzheimer's disease
- Citation
- Journal of Personalized Medicine, v.12, no.5
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Personalized Medicine
- Volume
- 12
- Number
- 5
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61047
- DOI
- 10.3390/jpm12050827
- ISSN
- 2075-4426
- Abstract
- Tissue inhibitor of metalloproteinase-3 (TIMP-3) is a component of the extracellular environment and is suggested to play an indirect role in regulating A beta production and the pathophysiology of A beta deposition in brains. However, studies on the amount of TIMP-3 in bodily fluids of Alzheimer's disease (AD) patients have not been conducted. Here, we investigated the relationship between fluid TIMP-3 levels and AD pathology. We first showed that the fluid levels of TIMP-3 were lower in AD dementia patients compared with in non-AD patients. ELISA results revealed that plasma levels of TIMP-3 in 65 patients with AD were significantly lower than those in 115 healthy control subjects and 71 mild cognitive impairment (MCI) subjects. Furthermore, we found that cerebrospinal fluid (CSF) level of TIMP-3 was decreased in AD compared with that in healthy control. These data suggest that fluid TIMP-3 levels negatively correlated with progress of cognitive decline. Collectively, our study suggests that alterations of fluid TIMP-3 levels might be associated with AD pathology.
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- Appears in
Collections - 2. Clinical Science > Department of Psychiatry > 1. Journal Articles
- 2. Clinical Science > Department of Neurology > 1. Journal Articles
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