Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Studyopen access
- Jung, Hee-Yeon; Jeon, Yena; Huh, Kyu Ha; Park, Jae Berm; Kim, Myung-Gyu; Lee, Sik; Han, Seungyeup; Ro, Han; Yang, Jaeseok; Ahn, Curie; Cho, Jang-Hee; Park, Sun-Hee; Kim, Yong-Lim; Kim, Chan-Duck
- Issue Date
- Blackwell Publishing Inc.
- kidney transplantation; alcohol; all-cause mortality; biopsy-proven acute rejection; cardiovascular events; death-censored graft failure; low-density lipoprotein cholesterol; total cholesterol
- Transplant International, v.35
- Journal Title
- Transplant International
- The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo, or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol (p < 0.001) and low-density lipoprotein cholesterol levels (p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels (p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile.
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- 2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles
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