Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Studyopen access

Authors
Jung, Hee-YeonJeon, YenaHuh, Kyu HaPark, Jae BermKim, Myung-GyuLee, SikHan, SeungyeupRo, HanYang, JaeseokAhn, CurieCho, Jang-HeePark, Sun-HeeKim, Yong-LimKim, Chan-Duck
Issue Date
May-2022
Publisher
Blackwell Publishing Inc.
Keywords
kidney transplantation; alcohol; all-cause mortality; biopsy-proven acute rejection; cardiovascular events; death-censored graft failure; low-density lipoprotein cholesterol; total cholesterol
Citation
Transplant International, v.35
Indexed
SCIE
SCOPUS
Journal Title
Transplant International
Volume
35
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61226
DOI
10.3389/ti.2022.10243
ISSN
0934-0874
Abstract
The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo, or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol (p < 0.001) and low-density lipoprotein cholesterol levels (p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels (p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Myung Gyu photo

Kim, Myung Gyu
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE