Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants
- Authors
- Kim, Sang-Hoon; Kim, Jihye; Jung, Sungmin; Noh, Ji Yun; Kim, Jinnam; Park, Heedo; Song, Young Goo; Peck, Kyong Ran; Park, Su-Hyung; Park, Man-Seong; Ko, Jae-Hoon; Song, Joon Young; Choi, Jun Yong; Jung, Min Kyung; Shin, Eui-Cheol
- Issue Date
- Jan-2024
- Publisher
- American Association for the Advancement of Science
- Citation
- Science immunology, v.9, no.91, pp eade6132
- Indexed
- SCIE
SCOPUS
- Journal Title
- Science immunology
- Volume
- 9
- Number
- 91
- Start Page
- eade6132
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65393
- DOI
- 10.1126/sciimmunol.ade6132
- ISSN
- 2470-9468
- Abstract
- Here, we examine peripheral blood memory T cell responses against the SARS-CoV-2 BA.4/BA.5 variant spike among vaccinated individuals with or without Omicron breakthrough infections. We provide evidence supporting a lack of original antigenic sin in CD8+ T cell responses targeting the spike. We show that BNT162b2-induced memory T cells respond to the BA.4/BA.5 spike. Among individuals with BA.1/BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.4/BA.5 spike increased. In a subgroup with BA.2 breakthrough infections, IFN-γ-producing CD8+ T cell responses against the BA.2-mutated spike region increased and correlated directly with responses against the BA.4/BA.5 spike, indicating that BA.2 spike-specific CD8+ T cells elicited by BA.2 breakthrough infection cross-react with the BA.4/BA.5 spike. We identified CD8+ T cell epitope peptides that are present in the spike of BA.2 and BA.4/BA.5 but not the original spike. These peptides are fully conserved in the spike of now-dominant XBB lineages. Our study shows that breakthrough infection by early Omicron subvariants elicits CD8+ T cell responses that recognize epitopes within the spike of newly emerging subvariants.
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- Appears in
Collections - 1. Basic Science > Department of Microbiology > 1. Journal Articles
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