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Retrospective Multicenter Analysis of Prognostic Risk Factors for One Year Recurrence in Patient With Renal Cell Carcinoma After Partial or Radical Nephrectomy: Results of Korean Renal Cancer Study Group (KRoCS) Databaseopen access

Authors
Choi, ChangilKang, MinyongSeo, Seong IlSuh, JungyoSong, CherynChung, JinsooKim, Sung HanPark, Jae YoungHwang, Eu ChangJeong, Chang WookKwak, CheolKim, Jung KwonHong, Sung-Hoo
Issue Date
Jan-2024
Publisher
대한의학회
Keywords
Early Metastasis; Prognosis; Recurrence; Renal Cell Carcinoma; Risk Factor; Survival
Citation
Journal of Korean Medical Science, v.39, no.3, pp e11
Indexed
SCIE
SCOPUS
KCI
Journal Title
Journal of Korean Medical Science
Volume
39
Number
3
Start Page
e11
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65404
DOI
10.3346/jkms.2024.39.e11
ISSN
1011-8934
1598-6357
Abstract
BACKGROUND: We sought to identify prognostic risk factors for one year recurrence in patient with renal cell carcinoma (RCC) after partial or radical nephrectomy. METHODS: We performed a retrospective study of 1,269 patients with RCC after partial or radical nephrectomy and diagnosed recurrence using Korean Renal Cancer Study Group (KRoCS) database between January 1991 and March 2017. Recurrence-free survival (RFS), and overall survival (OS) were calculated using the Kaplan-Meier method and multivariate Cox regression analysis were performed to evaluate independent prognostic factors for recurrence. RESULTS: The median patient age was 56 years and median follow-up period was 67 months. Multivariable analysis demonstrated BMI greater than or equal to 23 and less than 30 (vs. BMI less than 23, hazard ratio [HR]: 0.707, P = 0.020) reduced recurrence one year postoperatively. Eastern Cooperative Oncology Group performance status (ECOG PS) greater than or equal to 1 (vs. ECOG PS 0, HR: 1.548, P = 0.007), high pathological T stage (pT2 vs. pT1, HR: 2.622, P < 0.001; pT3 vs. pT1, HR: 4.256, P < 0.001; pT4 vs. pT1, HR: 4.558, P < 0.001), and tumor necrosis (vs. no tumor necrosis, HR: 2.822, P < 0.001) were independent predictive factors for early recurrence within one year in patients with RCC. Statistically significant differences on RFS and OS were found among pathological T stages (pT2 vs. pT1; pT3 vs. pT1; pT4 vs. pT1, all P < 0.001). CONCLUSION: This large multicenter study demonstrated ECOG PS greater than or equal to 1, high pathological T stage, tumor necrosis and BMI less than 23 were significant prognostic risk factors of early recurrence within one year in patients with RCC who underwent nephrectomy. © 2024 The Korean Academy of Medical Sciences.
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Ansan Hospital (Department of Urology, Ansan Hospital)
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