Is There a Difference in the Incidence of Depression between Radiation and Surgical Treatments in Patients with Prostate Cancer?open access
- Authors
- Tae, Bum Sik; Ahn, Sun Tae; Yoo, Jung Wan; Song, Min Sung; Choi, Hoon; Bae, Jae Hyun; Park, Jae Young
- Issue Date
- Jan-2024
- Publisher
- 대한남성과학회
- Keywords
- Depression; Prostatic neoplasms; Surgery; Radiotherapy
- Citation
- The World Journal of Men's Health, v.42, no.1, pp 237 - 244
- Pages
- 8
- Indexed
- SCIE
KCI
- Journal Title
- The World Journal of Men's Health
- Volume
- 42
- Number
- 1
- Start Page
- 237
- End Page
- 244
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65417
- DOI
- 10.5534/wjmh.230119
- ISSN
- 2287-4208
2287-4690
- Abstract
- Purpose: Patients with cancer have a high risk of depression. However, a few studies have assessed differences in the inci-dence of depression among patients with prostate cancer (PC) based on whether they received radiotherapy (RTx) or surgical treatment.Materials and Methods: We analyzed data from the National Health Insurance Sharing Service database regarding the entire Korean adult population with PC (n=210,924) between 2007 and 2017. The adjusted hazard ratios (HRs) of depression as-sociated with treatment were estimated using propensity score-matched Cox proportional hazards models and Kaplan-Meier survival analyses.Results: Our final cohort comprised 9,456 patients with PC; of which, 8,050 men underwent surgery. During a mean follow-up duration of 7.1 years, 503 (5.3%) patients were newly diagnosed with depression. A significant difference in the incidence of depression was noted between the RTx and surgery groups (RTx vs. surgery: 5.55% vs. 5.28%; p=0.011) in the unmatched cohort. In the matched cohort, older age (>= 70 years, HR: 1.596, p<0.001) and poor Charlson comorbidity index scores (HR: 1.232, p=0.039) were correlated with the risk of depression. In addition, the adjusted HR for depression in the surgery group was 0.843 (p=0.221) compared with that in the RTx group. Kaplan-Meier analyses revealed that no significant difference in the cumulative probability of persistent depression was detected between the RTx and surgery groups in matched cohort (p=0.3386).Conclusions: In this nationwide population-based study, no significant differences in the risk of depression were observed between the surgical and RTx groups.
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