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Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates

Authors
Seong, DuhwanChoi, YeonsunChoi, In CheulLee, JaebeomChoi, Jae HyukPark, Ji HunNam, Jae JunJu, JaewonRyoo, Hyun JaeKwak, DongheeLee, JoonyeolKim, Seong-GiKim, Dong HweePark, Jong WoongShin, MikyungSon, Donghee
Issue Date
Feb-2024
Publisher
WILEY-V C H VERLAG GMBH
Keywords
adhesive; nerve repair; neurorrhaphy; self-healing; stretchable
Citation
Advanced Materials
Indexed
SCIE
SCOPUS
Journal Title
Advanced Materials
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/65530
DOI
10.1002/adma.202307810
ISSN
0935-9648
1521-4095
Abstract
The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti-inflammation remains to be resolved. Herein, a sticky and strain-gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin-inspired hierarchical structure entailing strain-gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self-healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair. A key feature in the materials design of wet adhesive, "a sticky and strain-gradient artificial epineurium (SSGAE) with skin-inspired hierarchical structure entailing strain-gradient layers, Janus hydrophilic/hydrophobic surfaces, and even self-healing property", which enables immediate and stable neurorrhaphy, is reported. image
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Choi, In Cheul
Anam Hospital (Department of Orthopedic Surgery, Anam Hospital)
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